Faculty research interests
- Recyclable and biodegradable plastics
- Controlled drug release systems
- Biomedical or environmental sensors
My research group works with:
- Exploring effects of metals on human health, i.e. omics of lead (Pb), cadmium, mercury, arsenic in kids and steel mill workers in Oswego and Syracuse in the USA, Kolkata in India, and Tbilisi in Georgia;
- Studying metal-binding properties of proteins, e.g., the quenching of fluorescence of alpha-macroglobulin due to its binding to Pb;
- Using detection methods to measure stress biomolecules in novel matrixes, such as cortisol in hair;
- Developing modern biochemistry and omics teaching laboratory experiments.
May research group is interested in the following areas:
- Designing, synthesizing, and characterizing copper(I) coordination compounds;
- Investigating photoluminescent properties of copper(I) for applications in optoelectronics;
- Exploring mechanochemical syntheses as greener alternatives for traditional synthetic inorganic methods.
Martha D. Bruch
- Use of spectroscopic techniques, especially NMR, to probe the relationship between molecula structure and physical or chemical properties of a wide range of substances, including synthetic polymers, peptides, organic molecules, and modified silica surfaces.
- Total synthesis of heterocyclic natural products with medicinal and/or structural importance,
- Development of new synthetic organic reactions. Currently, we are involved in the discovery of new ligand for Ullman type aryl-aryl couplings,
- Development of new experiments for organic laboratory curriculum using microwave.
In our forensic research laboratory, we focus on developing analytical approaches for applications in toxicology, drug analysis, arson detection and chemical analysis of latent fingerprints:
- Developing methods for the determination of drugs used in Drug Facilitated Crimes (DFC) in biological samples using extraction techniques such as dispersive liquid-liquid microextraction (DLLME), solid-phase extraction and solid phase microextraction coupled to gas chromatography-mass spectrometry (GC-MS), liquid chromatography-mass spectrometry (LC-MS) and high performance liquid chromatography (HPLC).
- Investigating interferences from substrates in fire debris analysis, using solid-phase microextraction (SPME) coupled to gas chromatography-mass spectrometry (GC-MS).
- Investigating the effect of age and gender on the chemical composition of latent fingerprints, using liquid-liquid extraction, followed by derivatization and analysis with gas chromatography-mass spectrometry (GC-MS).
- Developing new experiments for forensic science laboratory curriculum.
Webe C. Kadima
Characterization of the Effects of Metal Ions’ Chemistries on the Allosteric Conformational Changes and Association of Proteins.
Investigations of Plants Used to treat Diabetes in the Democratic of Congo (DRC) including:
- Clinical Studies of the Anti-Hyperglycemic Effects in People with Diabetes performed in the DRC.
- Biochemical Studies of the Mechanisms of Action at SUNY Oswego.
- Isolation and Determination of the Structure of Anti-Diabetic compounds at SUNY Oswego.
- The major focus of our lab is the study of protein interactions involved in the activation and regulation of the complement system. The complement system is an important part of innate immunity, and misregulation can lead to inflammatory diseases. We specifically focus on complement component 3 (C3) and its interactions with other complement proteins as well as with thrombomodulin, a protein which is best known for its regulatory role in blood clotting. We use a variety of methods including hydrogen/deuterium exchange mass spectrometry (HDXMS) and fluorescence spectroscopy to investigate interactions between the proteins of interest.
- In another project, we are using a combination of computational and wet lab techniques to determine enzyme function. The target enzymes have structures available in the protein databank, but their function is unknown. This work is being used to create a research-style curriculum for the undergraduate biochemistry teaching lab.
The main focus of our research group is to develop analytical methods for:
- monitoring chemical pollutants, which negatively affect public health and the environment (air, water, soil and sediment media) and investigating the efficiency of possible removal/remediation techniques for these compounds,
- measuring/monitoring drugs in pharmaceutical products and biological media (in-vitro and in-vivo),
- analyzing flavors/off-flavors and toxic compounds (e.g. pesticides and preservatives) in food samples,
- analyzing organic compounds such as fragrances emitted from living flowers and plants.
The analytical techniques and instrumentations being used are solvent-free sampling/sample preparation techniques such as solid phase microextraction and needle trap devices, coupled to gas chromatography-mass spectrometry (GC-MS) and high performance liquid chromatography (HPLC); as well as spectroscopic instruments. .
- Great Lakes Fish Monitoring Program,
- Lake Ontario Air Deposition Study (LOADS),
- Congenerspecific analysis of PCBs in human placental tissues and serum; reductive dechlorination of PCBs in an anaerobic bioreactor systems and CDFs;
- Analysis of native Alaskan foods;
- Development of analytical methods for the determination/separation PCBs/PCTs in industrially contaminated sediments;
- Utilization of snapping turtles and zebra mussels as environmental biomonitors.
Research funding is provided through collaborative grants from USEPA, ATSDR, National Institutes of Environmental Health Sciences, NYS Great Lakes Protection Fund, Great Lakes Research Consortium, Great Lakes Commission, Alcan Aluminum Corporation, Novelis Corporation, and World Wildlife Federation.
Casey C. Raymond
My research group is interested in three areas listed below.
- In the first area, students will learn air-sensitive techniques, including the use of Schlenk lines and gloveboxes.
- Students will also learn common charaterization techniques, including UV-vis, IR, and NMR spectroscopies, mass spectrometry, electrochemistry, and X-ray crystallography.
- Students in the third area of research will learn separation techniques and characterization techniques of food and fermentation related systems.
Jeffery A. Schneider
My research group is interested in three areas listed below.
carbohydrate analysis of precursors to fermented beverages
heavy metal analysis of contaminated soils
synthesis and heavy metal retention properties of novel synthetic-soil stationary phases