Faculty research interests
My research group works with:
- Proteins involved in cardiovascular problems of children and adults exposed to heavy metals, lead and mercury in particular, using proteomic techniques;
- Expression of such proteins and their metal-binding properties, e.g., the study of alpha-macroglobulin and lead;
- Detection methods for biomolecules in novel matrixes, cortisol in hair, for example;
- Biochemistry and proteomic teaching laboratory experiments' development, such as lipids' analysis using MALDI.
The research focus of my group is the design, synthesis, and characterization of ligands for copper coordination chemistry. We are interested in investigating the photoluminescent properties of copper(I) for applications in optoelectronics.
Martha D. Bruch
Use of spectroscopic techniques, especially NMR, to probe the relationship between molecula structure and physical or chemical properties of a wide range of substances, including synthetic polymers, peptides, organic molecules, and modified silica surfaces.
- Total synthesis of heterocyclic natural products with medicinal and/or structural importance,
- Development of new synthetic organic reactions. Currently, we are involved in the discovery of new ligand for Ullman type aryl-aryl couplings,
- Development of new experiments for organic laboratory curriculum using microwave,
- Comparison of online vs face-to-face course medium for a chemistry course.
Webe C. Kadima
The main thrust of our research is to characterize the effects of metal ion chemistries in the association and allosteric conformational changes in proteins. These studies provide a fundamental understanding of the interplay between metal ion properties and conformational equilibria. A model currently used is the zinc-insulin hexamer, the pancreatic storage form of insulin. Association/
dissociation and conformational changes modulate the action of insulin in-vivo and the pharmaceutical properties of insulin preparations. Thus, our studies contribute to the understanding of basic chemical processes underlying the action of insulin in-vivo and in pharmaceutical preparations.
The major focus of our lab is the study of protein interactions involved in the activation and regulation of the complement system. The complement system is an important part of innate immunity, and misregulation can lead to inflammatory diseases. We specifically focus on complement component 3 (C3) and its interactions with other complement proteins as well as with thrombomodulin, a protein which is best known for its regulatory role in blood clotting. We use a variety of methods including hydrogen/deuterium exchange mass spectrometry (HDXMS) and fluorescence spectroscopy to investigate interactions between the proteins of interest.
In another project, we are using a combination of computational and wet lab techniques to determine enzyme function. The target enzymes have structures available in the protein databank, but their function is unknown. This work is being used to create a research-style curriculum for the undergraduate biochemistry teaching lab.
The main focus of our research group is to develop analytical methods for:
- monitoring chemical pollutants, which negatively affect public health and the environment (air, water, soil and sediment media) and investigating the efficiency of possible removal/remediation techniques for these compounds,
- measuring/monitoring drugs in pharmaceutical products and biological media (in-vitro and in-vivo),
- analyzing flavors/off-flavors and toxic compounds (e.g. pesticides and preservatives) in food samples,
- analyzing organic compounds such as fragrances emitted from living flowers and plants.
The analytical techniques and instrumentations being used are solvent-free sampling/sample preparation techniques such as solid phase microextraction and needle trap devices, coupled to gas chromatography-mass spectrometry (GC-MS) and high performance liquid chromatography (HPLC); as well as spectroscopic instruments. .
Great Lakes Fish Monitoring Program, Lake Ontario Air Deposition Study (LOADS), congenerspecific analysis of PCBs in human placental tissues and serum; reductive dechlorination of PCBs in an anaerobic bioreactor systems and CDFs; analysis of native Alaskan foods; development of analytical methods for the determination/separation PCBs/PCTs in industrially contaminated sediments; and utilization of snapping turtles and zebra mussels as environmental biomonitors. Research funding is provided through collaborative grants from USEPA, ATSDR, National Institutes of Environmental Health Sciences, NYS Great Lakes Protection Fund, Great Lakes Research Consortium, Great Lakes Commission, Alcan Aluminum Corporation, Novelis
Corporation, and World Wildlife Federation.
Casey C. Raymond
My research group is interested in three areas listed below. In the !rst two areas of research, students will learn air-sensitive techniques, including the use of Schlenk lines and gloveboxes. Students will also lear common charaterization techniques, including UV-vis, IR, and NMR spectroscopies, mass spectrometry, electrochemistry, and X-ray crystallography. Students in the third area of research will learn separation techniques and characterization techniques of food and fermentation related systems.
Jeffery A. Schneider
My research interests are in the areas of (1) carbohydrate analysis of fermentation products and (2) analysis of heavy metals in the environment.