Faculty profile

Peer reviewed papers (20 most recent papers out of 79 papers)

• Hibar DP, Adams HH et al. (2017). Novel genetic loci associated with hippocampal volume. Nat. Commun. doi: 10.1038ncomms13624.
• Adams HH, Hibar DP et al. (2016). Novel genetic loci underlying human intracranial volume identified through genome-wide association. Nat. Neurosci. doi:10.1038/nn.4398.
• Yao X, Yan J, Kim S, Nho K, Risacher SL, Inlow M, Moore JH, Saykin AJ, Shen L, for the Alzheimer’s Disease Neuroimaging Initiative (ADNI). (2016). Two-dimensional enrichment analysis for mining high-level imaging genetic associations. Brain Informatics. In press.
• Nho K, Horgusluoglu E, Kim S, Risacher SL, Kim D, Foroud T, Aisen PS, Peterson RC, Jack CR Jr, Shaw LM, Trojanowski JQ, Weiner MW, Green RC, Toga AW, Saykin AJ, ADNI. (2016). Integration of bioinformatics and imaging informatics for identifying rare PSEN1 variants in Alzheimer’s disease. BMC Med Genomics. doi: 10.1186/s12920-016-0190-9.
• Song A, Yan J, Kim S, Risacher SL,, Wong A, Saykin AJ, Shen L, Greene C, for the Alzheimer’s Disease Neuroimaging Initiative (ADNI). (2016). Network-based analysis of genetic variants associated with hippocampal volume in Alzheimer’s disease: a study of ADNI cohorts. BioData Mining, doi:10.1186/x13040-016-0082-8.
• Du L, Huang H, Yan J, Kim S, Risacher SL, Inlow M, Moore JH, Saykin AJ, Shen L, for the Alzheimer’s Disease Neuroimaging Initiative (ADNI). (2016). Structured Sparse Canonical Correlation Analysis for Brain Imaging Genetics: An Improved GraphNet Method. Bioinformatics. Doi:10.1093/bioinformatics/btw033. [PMID: 26801960].
• Du L, Huang H, Yan J, Kim S, Risacher SL, Inlow M, Moore JH, Saykin AJ, Shen L, for the Alzheimer's Disease Neuroimaging Initiative. (2016) Structured Sparse CCA for Brain Imaging Genetics via Graph OSCAR. BMC Systems Biology. 2016; in press
• Kim S, Nho K, Ramanan VK, Lai D, Foroud TM, Lane K, Murrell JR, Gao S, Hall KS, Unverzagt FW, Baiyewu O, Ogunniyi A, Gureje O, Kling MA, Doraiswamy PM, Kaddurah-Daouk R, Hendrie HC, Saykin AJ. (2015). Genetic influences on plasma homocysteine levels in African Americans and Yoruba Nigerians. Journal of Alzheimer’s Disease. doi: 10.3233/JAD-150651.
• Ramanan VK, Risacher SL, Nho K, Kim S, Shen L, McDonald BC, Yoder KK, Hutchins GD, West JD, Tallman EF, Gao S, Foroud TM, Farlow MR, De Jager PL, Bennett DA, Aisen PS, Petersen RC, Jack CR, Toga AW, Green RC, Jagust WJ, Weiner MW, Saykin AJ, for the Alzheimer’s Disease Neuroimaging Initiative (ADNI). (2015) GWAS of longitudinal amyloid accumulation on [18F]-florbetapir PET in Alzheimer’s disease implicates microglial activation gene IL1RAP. BRAIN, doi:10.1093/brain/awv231.
• Saykin AJ, Shen L, Yao X, Kim S, Nho K, Risacher SL, Ramanan VK, Foroud TM, Faber KM, Sarwar N, Munsi LM, Hu X, Soares HD, Potkin SG, Thompson PM, Kauwe JSK, Kaddurah-Daouk R, Green RC, Toga AW, Weiner MW, for the Alzheimer’s Disease Neuroimaging Initiative. (2015) Genetic Studies of Quantitative MCI and AD Phenotypes in ADNI: Progress, Opportunities, and Plans. Alzheimers and Dementia, doi:10.1016/j.jalz.2015.05.009.
• Nho K, Ramanan VK, Horgusluoglu E, Kim S, Inlow MH, Risacher SL, McDonald BC, Farlow MR, Foroud TM, Gao S, Callahan CM, Hendrie HC, Niculescu AB, Saykin AJ. (2015) Comprehensive Gene- and Pathway-Based Analysis of Depressive Symptoms in Older Adults. Journal of Alzheimer’s Disease, doi:10.3233/JAD-148009.
• Liang H, Meng X, Chen F, Zhang Q, Yan J, Yao X, Kim S, Wang L, Feng W, Saykin AJ, Li J, Shen L, and for the ADNI. (2015) A network-based framework for mining high-level imaging genetic associations. MICGen 2015: MICCAI Workshop on Imaging Genetics, October 9, 2015.
• Yan J, Du L, Kim S, Risacher SL, Huang H, Inlow M, Moore JH, Saykin AJ, Shen L, for the ADNI. (2015) BoSCCA: Mining stable imaging and genetic associations with implicit structure learning. MICGen 2015: MICCAI Workshop on Imaging Genetics, October 9, 2015.
• Yao X, Yan J, Kim S, Nho K, Risacher SL, Inlow M, Moore JH, Saykin AJ, Shen L, for the Alzheimer's Disease Neuroimaging Initiative. (2015) Two-dimensional enrichment analysis for mining high-level imaging genetic associations. BIH 2015: International Conference on Brain Informatics & Health, 30 August - 2 September 2015, London, UK.
• Du L, Yan J, Kim S, Risacher SL, Huang H, Inlow M, Moore JH, Saykin AJ, Shen L, for the ADNI. (2015) GN-SCCA: GraphNet sparse canonical correlation analysis for brain imaging genetics. BIH 2015: Special Session on Neuroimaging Data Analysis and Application, 30, August-2 September, 2015, London, UK.
• Hibar DP, Stein JL, Renteria ME, Arias-Vasquez A, Desrivieres S, et. al. (2015) Common genetic variants influence human subcortical brain structures. Nature, doi: 10.1038/nature14101.
• Nho K, Kim S, Risacher SL, Shen L, Corneveaux JJ, Swaminathan S, Lin H, Ramanan VK, Liu Y, Foroud TM, Inlow MH, Siniard AL, Reiman RA, Aisen PS, Petersen RC, Green RC, Jack CR, Jr., Weiner MW, Baldwin CT, Lunetta KL, Farrer LA, Study M, Furney SJ, Lovestone S, Simmons A, Mecocci P, Vellas B, Tsolaki M, Kloszewska I, Soininen H, AddNeuroMed C, McDonald BC, Farlow MR, Ghetti B, Indiana M, Aging S, Huentelman MJ, Saykin AJ, Alzheimer's Disease Neuroimaging I. (2015) Protective variant for hippocampal atrophy identified by whole exome sequencing. Annals of neurology, 77(3):547-52. http://dx.doi.org/10.1002/ana.24349
• Yan J, Kim S, Nho K, Chen R, Risacher SL, Moore JH, Saykin AJ, Shen L, and for the ADNI. (2015) Hippocampal Transcriptome-Guided Genetic Analysis of Correlated Episodic Memory Phenotypes in Alzheimer's Disease. Frontiers in Genetics, 6, doi: 10.3389/fgene.2015.00117
• Li J, Zhang Q, Chen F, Yan J, Kim S, Wang L, Feng W, Saykin AJ, Liang H, and Shen L (2015) Genetic interactions explain variance in cingulate amyloid burden: An AV-45 PET genome-wide association and interaction study in the ADNI cohort. BioMed Research International, Article ID 647389, doi:10.1155/2015/647389.
• Risacher SL, Kim S, Nho K, Foroud T, Shen L, Petersen RC, Jack CR, Beckett LA, Aisen PS, Koeppe RA, Jagust WJ, Shaw LM, Trojanowski JQ, Weiner MW, Saykin AJ, for the ADNI (2015) APOE effect on Alzheimer's biomarkers in older adults with significant memory concern. Alzheimers and Dementia, doi:10.1016/j.jalz.2015.03.003.

Peer-reviewed Conference Abstracts (18 most recent abstracts out of 84 abstracts)

• Liang H, Zhang Q, Meng X, Chen F, Yao X, Yan J, Kim S, Wang L, Feng W, Saykin AJ, Li J, Shen L, and for the ADNI. (2016) Genome-wide association and network analysis of the CSF biomarker Tau in the ADNI cohort. IIGC’16: 12th International Imaging Genetics Conference, Irvine, CA, Jan 18-19, 2016.
• Kim S, Nho K, Risacher SL, Shen L, Shaw LM, Trojanowski JQ, Weiner MW, Saykin AJ for the Alzheimer’s Disease Neuroimaging Initiative. (2015) MAPRE2 as a novel AD target gene from GWAS of CSF amyloid beta 1-42, tau and hyper-phosphorylated tau in the ADNI cohort. AAIC'15:Alzheimer's Association Int. Conf. on Alzheimer's Disease, Washington DC, USA, July 18-23, 2015.
• Kim S, Lai D, Lane K, Ramanan VK, Murrel JR, Gao S, Hall KS, Foroud TM, Baiyewu O, Ogunniyi A, Gureje O, Hendrie HC and Saykin AJ. (2015) Genome-wide association of plasma homocysteine in the Indianapolis-Ibadan Dementia study cohort. AAIC'15:Alzheimer's Association Int. Conf. on Alzheimer's Disease, Washington DC, USA, July 18-23, 2015.
• Kaddurah-Daouk R, Kling MA, Shaw LM, Arnold SE, Trojanowski JQ, Toledo JB, Saykin AJ, Kim S, Shen L, Han X, Goodenowe DB, Smith T, Senanayake V, and Doraiswamy PM. (2015) The Alzheimer’s metabolome: Identification of novel markers and treatment targets. AAIC'15:Alzheimer's Association Int. Conf. on Alzheimer's Disease, Washington DC, USA, July 18-23, 2015. [Platform talk]
• Risacher SL, Shen L, West JD, Zheng Y, Kim S, Nho K, Crane PK, Aisen PS, Petersen RC, Jack Jr. CR, Weiner MW, Saykin AJ and the Alzheimer’s Disease Neuroimaging Initiative. (2015) Effect of hypertension and antihypertensive medication on executive function, brain atrophy, and white matter hyperintensities. AAIC'15:Alzheimer's Association Int. Conf. on Alzheimer's Disease, Washington DC, USA, July 18-23, 2015. [Platform talk]
• Risacher SL, Kim S, Nho K, Jack Jr. CR, Jagust WJ, Aisen PS, Petersen RC, Weiner MW, Saykin AJ and the Alzheimer’s Disease Neuroimaging Initiative. (2015) Association of cerebral microhemorrhages with amyloid deposition and hyperlipidemia. AAIC'15:Alzheimer's Association Int. Conf. on Alzheimer's Disease, Washington DC, USA, July 18-23, 2015.
• Risacher SL, Kim S, Nho K, Shen L, Crane PK, Aisen PS, Petersen RC, Jack Jr. CR, Weiner MW, Saykin AJ, for the Alzheimer’s Disease Neuroimaging Initiative. (2015) Anticholinergic medication use in older adults is associated with memory and hippocampal volume. AAIC'15:Alzheimer's Association Int. Conf. on Alzheimer's Disease, Washington DC, USA, July 18-23, 2015.
• Ramanan VK, Risacher SL, Nho K, Kim S, Shen L, Foroud TM, Aisen PS, Petersen RC, Toga AW, Green RC, Jagust WJ, Weiner MW, Saykin AJ for the Alzheimer’s Disease Neuroimaging Initiative. (2015) GWAS of longitudinal amyloid PET identifies IL1RAP as a new potential AD target. AAIC'15:Alzheimer's Association Int. Conf. on Alzheimer's Disease, Washington DC, USA, July 18-23, 2015. [Platform talk]
• Nho K, Kim S, Risacher SL, Soares HD, Singh P, Wang L, Qi Z, He A, Neuhaus I, Patel V, Kim D, Foroud T, Faber KM, Apostolova L, Weiner MW and Saykin AJ. (2015) Gene expression profiling identifies altered networks in late onset Alzheimer’s disease: Immune response and mitochondrial process. AAIC'15:Alzheimer's Association Int. Conf. on Alzheimer's Disease, Washington DC, USA, July 18-23, 2015.
• Nho K, Kim S, Risacher SL, Foroud T, Aisen PS, Petersen RC, Jagust WJ, Jack Jr. CR, Shaw LM, Trojanowski JQ, Weiner MW, Green RC, Toga AW, Greicius MD and Saykin AJ. (2015) Influence of rare RELN variants on quantitative PET imaging and CSF phenotypes in late onset Alzheimer’s disease. AAIC'15:Alzheimer's Association Int. Conf. on Alzheimer's Disease, Washington DC, USA, July 18-23, 2015.
• Nho K, Kim S, Risacher SL, Ramanan VK, Shen L, Foroud T, Crane PK, Weiner MW, Green RC, Toga AW, and Saykin AJ. (2015) Genome-wide variant analysis identifies candidates genes significantly associated with composite scores for memory. AAIC'15:Alzheimer's Association Int. Conf. on Alzheimer's Disease, Washington DC, USA, July 18-23, 2015. [Platform talk]
• Deters KD, Nho K, Risacher SL, Kim S, Ramanan V, Crane PK, Saykin AJ and the Alzheimer’s Disease Neuroimaging Initiative. (2015) GWAS identifies GLI3 as a novel gene for language deficits and cortical changes in older adults at-risk for Alzheimer’s disease. AAIC'15:Alzheimer's Association Int. Conf. on Alzheimer's Disease, Washington DC, USA, July 18-23, 2015.
• Yao X, Yan J, Kim S, Nho K, Risacher SL, Borner K, Foroud TM, Thompson PM, Potkin SG, Sarwar N, Munsie L, Soares H, Green RC, Toga AW, Weiner MW, Saykin AJ, Shen L, and for the ADNI. (2015) Genetic findings using ADNI multimodal quantitative phenotypes: A 2014 update. AAIC'15:Alzheimer's Association Int. Conf. on Alzheimer's Disease, Washington DC, USA, July 18-23, 2015.
• Cong W, Meng X, Liang H, Zhang Q, Chen F, Feng W, Yan J, Kim S, Saykin AJ, Li J, Shen L, and for the ADNI. (2015) Genome-wide network-based pathway analysis of CSF biomarker t-tau in the ADNI cohort. AAIC'15: Alzheimer's Association Int. Conf. on Alzheimer's Disease, Washington DC, USA, July 18-23, 2015.
• Yan J, Kim S, Nho K, Yao X, Risacher SL, Moore JH, Saykin AJ, Shen L, and for the ADNI. (2015) The NAV2 (Neuron navigator 2) gene as a common genetic influence across correlated episodic memory performances.AAIC'15: Alzheimer's Association Int. Conf. on Alzheimer's Disease, Washington DC, USA, July 18-23, 2015.
• Yao X, Kim S, Yan J, Risacher SL, Inlow M, Moore JH, Saykin AJ, Shen L†§, and for the ADNI. (2015) Joint analysis of multiple amyloid imaging phenotypes in a genome wide association study of the ADNI cohort. IIGC’15: 11th International Imaging Genetics Conference, Irvine, CA, Jan 17-18, 2015.
• Zhang Q, Li J, Chen F, Yan J, Kim S, Wang L, Feng W, Saykin AJ, Liang H, Shen L†§, and for the ADNI. (2015) Genome-wide interaction study of amyloid imaging phenotypes in the ADNI cohort. IIGC’15: 11th International Imaging Genetics Conference, Irvine, CA, Jan 17-18, 2015. (Best Poster Award, 1st Place)
• Kim S, Nho K, Risacher SL, Rajagopalan P, Shen L, Shaw LM, Trojanowski JQ, Kling MA, Han X, Goodenowe D, Rotroff D, Motsinger AA, Doraiswamy PM, Kaddurah-Daouk R, Green RC, Toga AW, and Saykin AJ (2014) Whole gene-based association of baseline plasma homocysteine in the ADNI-1 cohort. AAIC'14: Alzheimer's Association Int. Conf. on Alzheimer's Disease, Copenhagen, Denmark, July 12-17, 2014.