From: web-form@Oswego.EDU
Sent: Saturday, December 01, 2007 2:29 PM
To: ucc@oswego.edu
Subject: Web Form: Course_Submission

Department_Chair: Jeffery Schneider
Department_Chair_Email: schneidr@oswego.edu
Additional_Contact: Fehmi Damkaci
Additional_Contact_Email: damkaci@oswego.edu

Course_Number: CHE455
Course_Type: New Course
Course_Title: Medicinal Chemistry

Catalog_Description: 
Designed for students who are interested in learning about drug discovery, drug design, and the molecular mechanisms by which drugs act. Topics include drug targets, pharmacokinetics, drug discovery, design, and development, and the chemistry of selected clinically important drugs.

Prerequisites: CHE 332 or instructor’s approval 
Fl_irregular basis: Yes
Semester_Hours: 3

Justification: A broad range of students, who are majoring in biology, chemistry, biochemistry, zoology, will benefit from this course. The course is of particular interest to students who might be considering a future career in the pharmaceutical industry or medicine. It attempts to convey something of the fascination of working in a field that overlaps the disciplines of chemistry, biochemistry, and pharmacology.

The course will be offered as dual course at undergraduate and graduate level. This is one of the reasons it is offered at 400 level. The course (with the same name) has been offered by other colleges as 400-level and dual course. 

CHE332 (organic chemistry) is a prerequisite for the course, since the course requires basic grounding in organic chemistry.

Total cap will be 25; 15 undergraduates and 10 graduates. The number of undergraduates may be increased up to 20 if needed, but we would like to keep the class size small, since it is a higher level course. 

It will be offered as an elective, since it is not a required course by American Chemical Society. 

Course_Objectives: 
•	To learn the basic principles of medicinal chemistry, including drug discovery, design and development, 
•	To learn the mechanisms of drug action and drug targets
•	To learn the pharmacokinetics (drug absorption, distribution, metabolism, excretion, administration, dosing, delivery),
•	To learn the action of selected clinically important drugs.
•	To become familiar with medicinal chemistry literature regarding drug development.

Course_Description: 
Course Outline: 

1- From Lab to your cabinet: Drug Discovery Process
2- Drug Targets: enzymes, receptors, nucleic acids and cell wall,
3- Pharmacokinetics (absorption, distribution, metabolism, excretion, dosing, delivery)
4- Drug Discovery
5- Drug Design
6- Drug Development
7- Antibacterial agents
8- Antiviral agents
9- Anticancer agents

Methods of Instruction:  
Methods of instruction will include lecturing using power point presentation, class discussions, invited expert lecturing on special topics, student presentations.

Assessment: 
Two midterms and a final exam, homework assignments, and a group project. 

Resources: chemistry related journals. In addition to what we have currently in library, access to journal of medicinal chemistry will be a great plus for this course but a not required.

Bibliography:

1. Graham L. Patrick, An Introduction to Medicinal Chemistry, 3rd ed., Oxford University Press: New York, 2005. (REQUIRED TEXT)

2. Richard B. Silverman, The Organic Chemistry of Drug Design and Drug Action, 2nd ed., Elsevier Academic Press: Boston, 2004.

3. David A. Williams and Thomas L. Lemke, Foye’s Principles of Medicinal Chemistry, 5th ed., Lippincott Williams & Wilkins: Philadelphia, 2002.

4. Gareth Thomas, Medicinal Chemistry: An Introduction, 4th ed., John Wiley & Sons: Chichester, 2006.

5. E.J. Corey, Barbara Czako, Laszlo Kurti, Molecules and Medicine, John Wiley & Sons: Hoboken, 2007

Other_Comments: This course proposal discussed at the departmental meeting and changes already made to fulfill the departmental requests/revisions.

IP_Adress: 129.3.17.156